解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Autoimmune lymphoproliferative syndrome (ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notably following splenectomy. We surveyed a cohort of 100 ALPS patients (including 33 splenectomize...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-02-553834
更新日期:2014-09-04 00:00:00
abstract::Peripheral T-cell lymphomas (PTCLs) are rare lymphomas with mostly poor outcome with current treatment. The addition of etoposide to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and upfront consolidation with autologous stem cell transplantation (auto-SCT) have shown promising results but have nev...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-04-573089
更新日期:2014-09-04 00:00:00
abstract::Anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a CD30-positive T-cell non-Hodgkin lymphoma that morphologically resembles ALK-positive ALCL but lacks chromosomal rearrangements of the ALK gene. The genetic and clinical heterogeneity of ALK-negative ALCL has not been delineated. We p...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-04-571091
更新日期:2014-08-28 00:00:00
abstract::Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages engaged in recycling of red cells were depleted from the tissues of Hmox1...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-02-554162
更新日期:2014-08-28 00:00:00
abstract::Treatment outcomes for older patients with acute myeloid leukemia (AML) have remained dismal. This randomized, phase 2 trial in AML patients not considered suitable for intensive induction therapy compared low-dose cytarabine (LDAC) with or without volasertib, a highly potent and selective inhibitor of polo-like kinas...
journal_title:Blood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1182/blood-2014-03-560557
更新日期:2014-08-28 00:00:00
abstract::Hematopoietic stem cell (HSC)-based gene therapy holds promise for the cure of many diseases. The field is now moving toward the use of lentiviral vectors (LVs) as evidenced by 4 successful clinical trials. These trials used vesicular-stomatitis-virus-G protein (VSV-G)-LVs at high doses combined with strong cytokine-c...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-02-558163
更新日期:2014-08-21 00:00:00
abstract::We studied the impact of driver mutations of JAK2, CALR, (calreticulin gene) or MPL on clinical course, leukemic transformation, and survival of patients with primary myelofibrosis (PMF). Of the 617 subjects studied, 399 (64.7%) carried JAK2 (V617F), 140 (22.7%) had a CALR exon 9 indel, 25 (4.0%) carried an MPL (W515)...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-05-578435
更新日期:2014-08-14 00:00:00
abstract::Proteasome inhibition is an effective treatment strategy for multiple myeloma. With improving survival, attention is increasingly focusing on ease of administration and toxicity profile. Ixazomib is an investigational, orally bioavailable 20S proteasome inhibitor. Sixty patients with relapsed and/or refractory multipl...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-01-548941
更新日期:2014-08-14 00:00:00
abstract::An estimated 22 350 patients had multiple myeloma diagnosed in 2013, representing 1.3% of all new cancers; 10 710 deaths are projected, representing 1.8% of cancer deaths. Approximately 0.7% of US men and women will have a myeloma diagnosis in their lifetime, and with advances in therapy, 77 600 US patients are living...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2014-03-544759
更新日期:2014-08-07 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population that shares certain characteristics including an aberrant myeloid phenotype and the ability to suppress T cells. MDSCs have been predominantly studied in malignant diseases and findings suggest involvement in tumor-associated immune suppress...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:10.1182/blood-2013-12-546416
更新日期:2014-07-31 00:00:00
abstract::In this issue of Blood, Lu et al describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG7112) and the pegylated interferon α (Peg-IFNα 2a) to target JAK2V617F hematopoietic progenitors and stem cells. Their work provides a rationale for the treatment of patients suffering fr...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2014-06-579623
更新日期:2014-07-31 00:00:00
abstract::Viral infections have been associated with reduced platelet counts, the biological significance of which has remained elusive. Here, we show that infection with encephalomyocarditis virus (EMCV) rapidly reduces platelet count, and this response is attributed to platelet Toll-like receptor 7 (TLR7). Platelet-TLR7 stimu...
journal_title:Blood
pub_type: 临床试验,杂志文章
doi:10.1182/blood-2013-11-536003
更新日期:2014-07-31 00:00:00
abstract::The phagocytic function of macrophages plays a pivotal role in eliminating apoptotic cells and invading pathogens. Evidence implicating plasminogen (Plg), the zymogen of plasmin, in phagocytosis is extremely limited with the most recent in vitro study showing that plasmin acts on prey cells rather than on macrophages....
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-01-549659
更新日期:2014-07-31 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) is widely used to treat hematopoietic cell disorders but is often complicated by graft-versus-host disease (GVHD), which causes severe epithelial damage. Here we have investigated longitudinally the effects of induction chemotherapy, conditioning radiochemother...
journal_title:Blood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1182/blood-2013-11-536888
更新日期:2014-07-31 00:00:00
abstract::The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and extracellular vesicles. Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell types, and they med...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-03-562439
更新日期:2014-07-24 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced pr...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-05-499707
更新日期:2014-07-17 00:00:00
abstract::Over the past 5 years, many novel approaches to early diagnosis, prevention, and treatment of acute graft-versus-host disease (aGVHD) have been translated from the bench to the bedside. In this review, we highlight recent discoveries in the context of current aGVHD care. The most significant innovations that have alre...
journal_title:Blood
pub_type: 杂志文章,评审
doi:10.1182/blood-2014-01-514786
更新日期:2014-07-17 00:00:00
abstract::Pregnancy can precipitate thrombotic thrombocytopenic purpura (TTP). We present a prospective study of TTP cases from the United Kingdom Thrombotic Thrombocytopenic Purpura (UK TTP) Registry with clinical and laboratory data from the largest cohort of pregnancy-associated TTP and describe management through pregnancy,...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-02-553131
更新日期:2014-07-10 00:00:00
abstract::Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remai...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-03-561027
更新日期:2014-07-03 00:00:00
abstract::The outcome of patients with acute myeloid leukemia who are older than 60 years has remained poor because of unfavorable disease characteristics and patient-related factors. The randomized German-Austrian AML Study Group 06-04 protocol was designed on the basis of in vitro synergistic effects of valproic acid (VPA) an...
journal_title:Blood
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1182/blood-2013-12-546283
更新日期:2014-06-26 00:00:00
abstract::Although much of the function of von Willebrand factor (VWF) has been revealed, detailed insight into the molecular structure that enables VWF to orchestrate hemostatic processes, in particular factor VIII (FVIII) binding and stabilization in plasma, is lacking. Here, we present the high-resolution solution structure ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-07-517086
更新日期:2014-06-26 00:00:00
abstract::Protein S is a cofactor for tissue factor pathway inhibitor (TFPI), accelerating the inhibition of activated factor X (FXa). TFPI Kunitz domain 3 residue Glu226 is essential for enhancement of TFPI by protein S. To investigate the complementary functional interaction site on protein S, we screened 44 protein S point, ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-01-551812
更新日期:2014-06-19 00:00:00
abstract::Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorgan system cGVHD and associated bronchiolitis obliterans syndrome (BOS...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-03-562231
更新日期:2014-06-19 00:00:00
abstract::In this issue of Blood, Bachanova et al describe how modulation of the inhibitory tumor environment may enhance natural killer (NK) cell clinical activity and produce encouraging results in the treatment of refractory acute myeloid leukemia (AML). NK cells are highly proliferative, early responders of the innate immun...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2014-05-570291
更新日期:2014-06-19 00:00:00
abstract::Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis with elevated cell-free hemoglobin and heme. The ensuing depletion of heme scavenger proteins leads to nonspecific heme uptake and h...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-529982
更新日期:2014-06-12 00:00:00
abstract::There is growing evidence that lymphocyte trafficking contributes to the clinical course of chronic lymphocytic leukemia (CLL), but to date, only static in vitro cultures have been used to study these phenomena. To address this lack of data, we have developed a dynamic in vitro model in which CLL cells experience shea...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-12-544569
更新日期:2014-06-05 00:00:00
abstract::The existence of spontaneous heparin-induced thrombocytopenia (HIT) syndrome (or autoimmune HIT), defined as a transient prothrombotic thrombocytopenic disorder without proximate heparin exposure serologically indistinguishable from HIT, is controversial. We describe 2 new cases presenting with thrombotic stroke/throm...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-01-549741
更新日期:2014-06-05 00:00:00
abstract::Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder. Hepcidin is produced mainly b...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2014-01-550467
更新日期:2014-06-05 00:00:00
abstract::Activation of sialic-acid-binding immunoglobulin-like lectin-G (Siglec-G) by noninfectious damage-associated molecular patterns controls innate immune responses. However, whether it also regulates T-cell-mediated adaptive immune responses is not known. Graft-versus-host reaction is a robust adaptive immune response ca...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-12-545335
更新日期:2014-05-29 00:00:00
abstract::In systemic light-chain amyloidosis, λ light chains produced by clonal plasma cells cause organ damage and early death. In pursuit of novel therapy, we developed 1 pool of short interfering RNA (siRNA) targeting the constant region of λ light chains that substantially and promptly reduces λ-light-chain production and ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-535187
更新日期:2014-05-29 00:00:00
abstract::C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors such as imatinib mesylate (imatinib) are effective in managing chronic myeloid leukemia (CML) but incapable of eliminating leukemia stem cells (LSCs), suggesting that kinase-independent pathways support LSC survival. Given that the bone marrow (BM)...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-07-511907
更新日期:2014-05-22 00:00:00
abstract::In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting the cytoplasmic proteins talin and kindlin to the β3 cytoplasmic tail. ...
journal_title:Blood
pub_type: 评论,杂志文章
doi:10.1182/blood-2014-02-557355
更新日期:2014-05-15 00:00:00
abstract::The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Rema...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-11-538678
更新日期:2014-05-15 00:00:00
abstract::Serum response factor (SRF) is a ubiquitously expressed transcription factor and master regulator of the actin cytoskeleton. We have previously shown that SRF is essential for megakaryocyte maturation and platelet formation and function. Here we elucidate the role of SRF in neutrophils, the primary defense against inf...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-06-507582
更新日期:2014-05-08 00:00:00
abstract::Richter syndrome (RS) is associated with poor outcome. The prognosis of patients with histologically aggressive chronic lymphocytic leukemia (CLL), or HAC, has not been studied. We aimed to correlate 2-deoxy-2-[(18)F]fluoroglucose/positron emission tomography (FDG/PET) data, histological diagnosis, clinical characteri...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-11-536169
更新日期:2014-05-01 00:00:00
abstract::The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular injury. Unexpectedly, we observed platelets translocating over A1A2A3 domains protein slower than on A1 domain at high shear stress. This observ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-530428
更新日期:2014-04-24 00:00:00
abstract::There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in inflammatory processes. Here we report that neutrophils have to be simultaneously activated by integrin-mediated outside-in- and G-protein-coupled receptor (GPCR) signaling to induce NET formation in acute lung injury (ALI), ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-07-516484
更新日期:2014-04-17 00:00:00
abstract::Monoclonal gammopathy of undetermined significance (MGUS) is present in ∼2% of individuals age >50 years. The increased risk of multiple myeloma (MM) in relatives of individuals with MGUS is consistent with MGUS being a marker of inherited genetic susceptibility to MM. Common single-nucleotide polymorphisms (SNPs) at ...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-532283
更新日期:2014-04-17 00:00:00
abstract::Nucleophosmin-mutated acute myeloid leukemia (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Because miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs co...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-10-532374
更新日期:2014-04-10 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward leukemic transformation. We used targeted next-generation sequencing (NGS) of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clo...
journal_title:Blood
pub_type: 杂志文章
doi:10.1182/blood-2013-11-537167
更新日期:2014-04-03 00:00:00